Investigating <i>Bordetella pertussis</i> colonisation and immunity: protocol for an inpatient controlled human infection model.

ABSTRACT:

Introduction

We summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally Bordetella pertussis is one of the leading causes of vaccine-preventable death. Many countries have replaced whole cell vaccines with acellular vaccines over the last 20 years during which pertussis appears to be resurgent in a number of countries in the developed world that boast high immunisation coverage. The acellular vaccine provides relatively short-lived immunity and, in contrast to whole cell vaccines, may be less effective against colonisation and subsequent transmission. To improve vaccine strategies, a greater understanding of human B. pertussis colonisation is required. This article summarises a protocol and does not

SUBMITTER: de Graaf H 

PROVIDER: S-EPMC5652574 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature