Longitudinal Change in Fasting Blood Glucose and Myocardial Infarction Risk in a Population Without Diabetes.

ABSTRACT:

Objective

To examine the change in fasting blood glucose (FBG) during repeated assessments over time and its potential impact on the risk of developing myocardial infarction (MI).

Research design and methods

This prospective cohort study included 68,297 participants without diabetes (mean age 49 years) who were free of MI, stroke, and cancer prior to or in 2010 (baseline of the current analysis). FBG concentrations were measured in 2006, 2008, and 2010. The FBG trajectories during 2006-2010, the primary exposure of the current study, were identified by latent mixture modeling. Incident MI cases were confirmed via review of medical records by cardiologists.

Results

We identified five discrete FBG trajectories according to FBG range and changing pattern over time: eleva

SUBMITTER: Jin C 

PROVIDER: S-EPMC5652588 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature