Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.

ABSTRACT: Tbx15 is a member of the T-box gene family of mesodermal developmental genes. We have recently shown that Tbx15 plays a critical role in the formation and metabolic programming of glycolytic myofibers in skeletal muscle. Tbx15 is also differentially expressed among white adipose tissue (WAT) in different body depots. In the current study, using three independent methods, we show that even within a single WAT depot, high Tbx15 expression is restricted to a subset of preadipocytes and mature white adipocytes. Gene expression and metabolic profiling demonstrate that the Tbx15^Hi preadipocyte and adipocyte subpopulations of cells are highly glycolytic, whereas Tbx15^Low preadipocytes and adipocytes in the same depot are more oxidative and less glycolyti

SUBMITTER: Lee KY 

PROVIDER: S-EPMC5652605 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature