Statin use and risk of developing diabetes: results from the Diabetes Prevention Program.

ABSTRACT:

Objective

Several clinical trials of cardiovascular disease prevention with statins have reported increased risk of type 2 diabetes (T2DM) with statin therapy. However, participants in these studies were at relatively low risk for diabetes. Further, diabetes was often based on self-report and was not the primary outcome. It is unknown whether statins similarly modify diabetes risk in higher risk populations.

Research design and methods

During the Diabetes Prevention Program Outcomes Study (n=3234), the long-term follow-up to a randomized clinical trial of interventions to prevent T2DM, incident diabetes was assessed by annual 75 g oral glucose tolerance testing and semiannual fasting glucose. Lipid profile was measured annually, with statin treatment determined by a particip

SUBMITTER: Crandall JP 

PROVIDER: S-EPMC5652620 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature