Ascites-derived IL-6 and IL-10 synergistically expand CD14⁺HLA-DR^-/low myeloid-derived suppressor cells in ovarian cancer patients.

ABSTRACT: Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including ovarian cancer (OC). In this study, we characterized CD14⁺HLA-DR^-/lo MDSC with a typical monocytic phenotype (M-MDSC) in the peripheral blood (PB) and ascites from OC patients. Compared to healthy donors, OC patients had a significantly increased abundance of M-MDSC in both PB and ascites; importantly, their abundance in both compartments was inversely associated with the prognosis where OC patients with higher level of M-MDSC having a shorter relapse-free survival. Intriguingly, we demonstrated that M-MDSC could be readily induced by ascitic fluids (AF) from OC patients, which was predominantly dependent on IL-6, IL-10 and STAT3 activation as neutralization

SUBMITTER: Wu L 

PROVIDER: S-EPMC5652747 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature