Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide.

ABSTRACT: Doxorubicin, a widely used chemotherapeutic drug, has several potential high-risk side effects including cardiomyopathy. Furthermore, cellular resistance to this drug develops with time. By using liposomes as carrier vesicles both the side effects and drug resistance might be avoided. In this study we have investigated the cytotoxic effect of doxorubicin encapsulated in liposomes with and without ceramides containing 6 or 12 carbon atoms in the N-amidated fatty acyl chains. The short-chain ceramide species were included in the liposomal compositions due to their pro-apoptotic properties, which might cause a synergistic anticancer effect. We demonstrate that the ceramide species enhance the liposomal doxorubicin toxicity in a cell-specific manner. The C6-ceramide effect is most pronounced i

SUBMITTER: Overbye A 

PROVIDER: S-EPMC5652752 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature