TERT promoter status and gene copy number gains: effect on TERT expression and association with prognosis in breast cancer.

ABSTRACT: Upregulation of the telomerase reverse transcriptase (TERT) gene in human cancers leads to telomerase activation, which contributes to the growth advantage and survival of tumor cells. Molecular mechanisms of TERT upregulation are complex, tumor-specific and can be clinically relevant. To investigate these mechanisms in breast cancer, we sequenced the TERT promoter, evaluated TERT copy number changes and assessed the expression of the MYC oncogene, a known transcriptional TERT regulator, in two breast cancer cohorts comprising a total of 122 patients. No activating TERT promoter mutations were found, suggesting that this mutational mechanism is not likely to be involved in TERT upregulation in breast cancer. The T349C promoter polymor

SUBMITTER: Gay-Bellile M 

PROVIDER: S-EPMC5652798 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature