Chronic obstructive pulmonary disease and risk of lung cancer: a meta-analysis of prospective cohort studies.

ABSTRACT:

Background

Studies exploring the association between chronic obstructive pulmonary disease (COPD) and lung cancer have yielded mixed results. We conducted a meta-analysis of the published prospective cohort studies to have a clear understanding about this association.

Methods

We searched the MEDLINE and EMBASE databases from inception to December 31, 2016. Bibliographies were also reviewed for additional information. Random-effects model was used to calculate summary relative risk (SRR) and corresponding 95% confidence interval (CI).

Results

Eighteen prospective cohort studies were part of this meta-analysis, involving 12,442 lung cancer cases with a median duration of follow- up of 5 years (range: 1.5-20 years). A history of COPD, emphysema or chronic bronchitis conf

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5652835 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature