Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma.

ABSTRACT: Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced stage and current treatments are limited. Identifying new diagnostic and therapeutic targets for mesothelioma remains a priority, particularly for the new wave of victims exposed to asbestos through do-it-yourself renovations and in countries where asbestos is still mined and used. Recent advances have demonstrated a biological role for the small but powerful gene regulators microRNA (miRNA) in mesothelioma. A number of potential therapeutic targets have been identified. MiRNA have also become popular as potential biomarke

SUBMITTER: Birnie KA 

PROVIDER: S-EPMC5652849 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature