Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging.

ABSTRACT:

Objective

This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men.

Methods

Forty-two 40- to 60-year-old cognitively normal women (15 asymptomatic perimenopausal by age [CNT], 13 perimenopausal [PERI], and 14 postmenopausal [MENO]) and 18 age- and education-matched men were examined. All patients had volumetric MRI, ¹⁸F-fluoro-2-deoxyglucose (FDG)-PET (glucose metabolism), and Pittsburgh compound B-PET scans (β-amyloid [Aβ] deposition, a hallmark of AD pathology).

Results

As expected, the MENO group was older than the PERI and CNT groups. Otherwise, groups were comparable

SUBMITTER: Mosconi L 

PROVIDER: S-EPMC5652968 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature