Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-analysis.

ABSTRACT:

Background

Beta-blockers are first-line therapy in patients with congenital long-QT syndrome (LQTS).

Objective

This study sought to determine the differences in effectiveness of beta-blockers on risk reduction according to LQTS genotype.

Methods

We searched MEDLINE, EMBASE, and CENTRAL databases to investigate the use of beta-blockers (atenolol, nadolol, propranolol, and metoprolol) in patients with LQTS. Hazard ratio (HR) and relative risk (RR) were extracted or calculated from studies reporting cardiac events (syncope, aborted cardiac arrest (ACA), or sudden cardiac death (SCD)).

Results

Among 2,113 articles searched, 10 studies (7 registry-based cohort studies (Cohort) and 3 interrupted time series studies (ITS)) involving 9,727 patients were included. In a

SUBMITTER: Ahn J 

PROVIDER: S-EPMC5653191 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature