Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.

ABSTRACT: The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4⁺ T cell depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 was shown to reduce viral transmission, delay disease progression, and induce persistent virus control in macaques challenged with simian immunodeficiency virus (SIV). We show that integrin α4β7 is efficiently incorporated into the envelope of HIV-1 virions. Incorporated α4β7 is functionally active as it binds mucosal addressin cell adhesion molecule-1 (MAdCAM-1), promoting HIV-1 capture by and infection of MAdCAM-expressing cells, which in turn mediate trans-infection of bystander cells. Functional α4β7 is present in circulating virions from HIV-infected patients and SIV-infected macaques, with peak level

SUBMITTER: Guzzo C 

PROVIDER: S-EPMC5653278 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature