Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo³¹P MRS study.

ABSTRACT: Evidence from ³¹P magnetic resonance spectroscopy (³¹P MRS) studies suggest that different psychiatric disorders, which typically emerge during adolescence and young adulthood, are associated with abnormalities in mitochondrial bioenergetics and membrane phospholipid metabolism. These disorders are also associated with deficits in omega-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) which accumulates in mitochondrial and synaptic membranes. The present study investigated the effects of dietary-induced alterations in brain DHA accrual during adolescence on phospholipid metabolism and bioenergetics in the adult rat brain using ³¹P MRS. During the peri-adolescent period (P21-P90), male rats were fed a diet with no n-3 fatty acid

SUBMITTER: Lindquist DM 

PROVIDER: S-EPMC5653412 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature