Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings.

ABSTRACT:

Background

Acute Chest Syndrome (ACS) is one of the leading causes of death among children with Sickle Cell Disease (SCD). Disruption of microvascular integrity is critical to the pathophysiology of ACS, but the factors governing its phenotypic variability are incompletely understood. Because circulating exosomes have been implicated in vascular dysfunction in various diseases, we hypothesized that exosomes induce endothelial dysfunction in patients who experience ACS.

Procedure

Cross-sectional cohort study including 33 outpatients with SCD (without new health-related complaints or recent transfusions) and a cohort of control patients. Exosomes were isolated from platelet-free plasma.

Results

ImageStream showed that exosome counts were greatly increased in patients wi

SUBMITTER: Lapping-Carr G 

PROVIDER: S-EPMC5653417 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature