Changes in Adult BMI and Waist Circumference Are Associated with Increased Risk of Advanced Colorectal Neoplasia.

ABSTRACT:

Background

Waist circumference (WC) is a stronger predictor of colon cancer (CRC) risk than body mass index (BMI). However, how well change in either WC or BMI predicts risk of advanced colorectal neoplasia (AN) is unclear.

Aims

To determine the relationship between change in BMI and WC from early adulthood to later age and the risk of AN and which change measure is a stronger predictor.

Methods

In 4500 adults, ages 50-80, with no previous neoplasia and undergoing screening colonoscopy, BMI and WC at age 21 and at time of screening were reported. Changes in BMI and WC were defined using universal risk cutoffs. Known CRC risk factors were controlled in the logistic models.

Results

Overall, model statistics showed WC change (omnibus test χ ² = 10.15, 2

SUBMITTER: Gathirua-Mwangi WG 

PROVIDER: S-EPMC5653429 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature