Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.

ABSTRACT: Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanisms underlying transcription factor binding variations in mammals. Our results highlight the pre-eminence of cis-acting variants on transcription factor occupancy divergence. Transcription factor binding differences linked to cis-acting variants generally exhibit additive inheritance, while those linked to trans-acting variants are most often dominantly inherited. Cis-acting variants lead to local coordination of transcription factor occupancies that decay with distance; distal coordination is als

SUBMITTER: Wong ES 

PROVIDER: S-EPMC5653656 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature