The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks.

ABSTRACT: We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to the processing of emotional stimuli, which is increasingly recognized to be a key factor in ADHD-related impairment. The executive control and default mode brain networks play an important role in the regulation of emotion processing, and altered connectivity of these networks has also been associated with ADHD. We therefore investigated whether resting-state connectivity of either of these networks mediates the relation of 5-HTTLPR and stress exposure with ADHD severity. Resting-state functional magnetic resonance imaging, genetic, and stress

SUBMITTER: van der Meer D 

PROVIDER: S-EPMC5653701 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature