Elucidation of Plasma-induced Chemical Modifications on Glutathione and Glutathione Disulphide.

ABSTRACT: Cold atmospheric pressure plasmas are gaining increased interest in the medical sector and clinical trials to treat skin diseases are underway. Plasmas are capable of producing several reactive oxygen and nitrogen species (RONS). However, there are open questions how plasma-generated RONS interact on a molecular level in a biological environment, e.g. cells or cell components. The redox pair glutathione (GSH) and glutathione disulphide (GSSG) forms the most important redox buffer in organisms responsible for detoxification of intracellular reactive species. We apply Raman spectroscopy, mass spectrometry, and molecular dynamics simulations to identify the time-dependent chemical modifications on GSH and GSSG that are caused by dielectric barrier discharge under ambient conditions. We find G

SUBMITTER: Klinkhammer C 

PROVIDER: S-EPMC5653798 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature