The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer.

ABSTRACT: The treatment paradigm of non-small cell lung cancer (NSCLC) has evolved into oncogene-directed precision medicine. Identifying actionable genomic alterations is the initial step towards precision medicine. An important scientific progress in molecular profiling of NSCLC over the past decade is the shift from the traditional piecemeal fashion to massively parallel sequencing with the use of next-generation sequencing (NGS). Another technical advance is the development of liquid biopsy with great potential in providing a dynamic and comprehensive genomic profiling of NSCLC in a minimally invasive manner. The integration of NGS with liquid biopsy has been demonstrated to play emerging roles in genomic profiling of NSCLC by increasing evidences. This review summarized the potential applicatio

SUBMITTER: Zhang YC 

PROVIDER: S-EPMC5654124 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature