Identification of Diverse Adenosine-to-Inosine RNA Editing Subtypes in Colorectal Cancer.

ABSTRACT:

Purpose

RNA editing generates protein diversity by altering RNA sequences in coding regions without changing the overall DNA sequence. Adenosine-to-inosine (A-to-I) RNA editing events have recently been reported in some types of cancer, but they are rare in human colorectal cancer (CRC). Therefore, this study was conducted to identify diverse RNA editing in CRC.

Materials and methods

We compared transcriptome data of 39 CRC samples and paired adjacent tissues from The Cancer Genome Atlas database to identify RNA editing patterns in CRC, focusing on canonical A-to-I RNA edits in coding sequence regions. We investigated nonsynonymous RNA editing patterns by comparing tumor and normal tissue transcriptome data.

Results

The number of RNA edits varied from 12 to 42 per sam

SUBMITTER: Lee SH 

PROVIDER: S-EPMC5654148 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature