Patient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies.

ABSTRACT:

Purpose

Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic similarities to the primary patient tissues and evaluated their potential for use as a platform for translational EOC research.

Materials and methods

We successfully established PDXs by subrenal capsule implantation of primary EOC tissues into female BALB/C-nude mice. The rate of successful PDX engraftment was 48.8% (22/45 cases). Hematoxylin and eosin staining and short tandem repeat analysis showed histopathological and genetic similarity between the PDX and primary patient tissues.

Results

Patients whose tumors were successfully engrafted in mice h

SUBMITTER: Heo EJ 

PROVIDER: S-EPMC5654149 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature