Genetic Alterations and Their Clinical Implications in High-Recurrence Risk Papillary Thyroid Cancer.

ABSTRACT:

Purpose

Papillary thyroid carcinomas (PTCs) frequently involve genetic alterations. The objective of this study was to investigate genetic alterations and further explore the relationships between these genetic alterations and clinicopathological characteristics in a high-recurrence risk (node positive, N1) PTC group.

Materials and methods

Tumor tissue blocks were obtained from 240 surgically resected patients with histologically confirmed stage III/IV (pT3/4 or N1) PTCs. We screened gene fusions using NanoString's nCounter technology and mutational analysis was performed by direct DNA sequencing. Data describing the clinicopathological characteristics and clinical courses were retrospectively collected.

Results

Of the 240 PTC patients, 207 (86.3%) had at least one ge

SUBMITTER: Lee MY 

PROVIDER: S-EPMC5654158 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature