Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis.

ABSTRACT:

Introduction

Genetic factors including the level of expression of the fingerprint of genes involved in the development of bones and cartilage such as GDF-5 or ESR-α or CALM-1 are known to be strong determinants of the osteoarthritis (OA) in Caucasian and Oriental populations. Because of high prevalence of OA in Indian population and availability of limited genetic data, we determined whether similar genetic factors are involved in Indians as well.

Methods

A case control study was carried out involving 500 patients of knee OA and equal number of healthy controls. Genotyping analyses in whole blood, mRNA, and protein expressions in peripheral blood lymphocytes (PBLs) were performed using established protocols.

Results

Our results showed a significantly decreased

SUBMITTER: Mishra A 

PROVIDER: S-EPMC5654253 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature