General principles of binding between cell surface receptors and multi-specific ligands: A computational study.

ABSTRACT: The interactions between membrane receptors and extracellular ligands control cell-cell and cell-substrate adhesion, and environmental responsiveness by representing the initial steps of cell signaling pathways. These interactions can be spatial-temporally regulated when different extracellular ligands are tethered. The detailed mechanisms of this spatial-temporal regulation, including the competition between distinct ligands with overlapping binding sites and the conformational flexibility in multi-specific ligand assemblies have not been quantitatively evaluated. We present a new coarse-grained model to realistically simulate the binding process between multi-specific ligands and membrane receptors on cell surfaces. The model simplifies each receptor and each binding site in a multi-spec

SUBMITTER: Chen J 

PROVIDER: S-EPMC5654264 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature