Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity.

ABSTRACT:

Background and objectives

Few birth cohorts have prospectively followed development of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities to determine timing, extent of co-occurrence, and associated genetic and demographic factors.

Methods

In this prospective birth cohort study, 8676 children at high genetic risk of both diseases were enrolled and 5891 analyzed in median follow-up of 66 months. Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed.

Results

Development of persistent islet autoantibodies (IAs) and tissue transglutaminase autoantibodies (tTGAs), as well as each clinical disease, was evaluated quarterly from 3 to 48 months of age and semiannually thereafter. IAs a

SUBMITTER: Hagopian W 

PROVIDER: S-EPMC5654393 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature