Meta-analysis of the correlation between vitamin D and lung cancer risk and outcomes.

ABSTRACT: In this meta-analysis, we analyzed the association between vitamin D levels and lung carcinoma risk and outcomes. Two authors independently searched the Web of Science, Pubmed, EBSCO and Ovid MEDLINE resources with the key words "vitamin D, lung cancer, solar and latitude" and enrolled 22 studies that satisfied the inclusion criteria. The summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the random (or fixed)-effects model. Potential confounders were carefully adjusted. High vitamin D (or calcium) intake and serum 25(OH)D levels each correlated inversely with lung cancer risk [OR = 0.72 (95% CI: 0.61-0.85, p < 0.001) and OR = 0.89 (95% CI: 0.83-0.97, p < 0.05)]. High circulating 25(OH)D levels also reduced lung cancer mortality with the poole

SUBMITTER: Liu J 

PROVIDER: S-EPMC5655260 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature