Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential.

ABSTRACT: Magnesium stearate is widely used in the production of dietary supplement and pharmaceutical tablets, capsules and powders as well as many food products, including a variety of confectionery, spices and baking ingredients. Although considered to have a safe toxicity profile, there is no available information regarding its potential to induce genetic toxicity. To aid safety assessment efforts, magnesium sulfate was evaluated in a battery of tests including a bacterial reverse mutation assay, an in vitro chromosome aberration assay, and an in vivo erythrocyte micronucleus assay. Magnesium stearate did not produce a positive response in any of the five bacterial strains tested, in the absence or presence of metabolic activation. Similarly, exposure to magnesium stearate did not lead to chromo

SUBMITTER: Hobbs CA 

PROVIDER: S-EPMC5655391 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature