Transcriptome Profiling Uncovers Potential Common Mechanisms in Fetal Trisomies 18 and 21.

ABSTRACT: Human trisomies have recently been investigated using transcriptomics approaches to identify the gene expression (GE) signatures characteristic of each of these specific aneuploidy conditions. We hypothesized that the viability of cells with gross genomic imbalances might be associated with the activation of resilience mechanisms that are common to different trisomies and that are reflected by specific shared GE patterns. We report in this article our microarray GE analyses of amniocytes from fetuses with viable trisomy conditions, trisomy 21 or trisomy 18, to detect such common expression signatures. Comparative analysis of significantly differentially expressed genes in trisomies 18 and 21 revealed six dysregulated genes common to both: OTUD5, ADAMTSL1, TADA2A, PPID, PIAS2, and MAPRE2. T

SUBMITTER: Volk M 

PROVIDER: S-EPMC5655413 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature