Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection.

ABSTRACT:

Background/aims

Long-term follow-up studies validating the clinical benefit of sustained virological response (SVR) in people with chronic hepatitis C (CHC) infection are lacking. Our aim was to identify rates and predictors of liver fibrosis progression in a large, well characterized cohort of CHC patients in whom paired liver fibrosis assessments were performed more than 10 years apart.

Methods

CHC patients who had undergone a baseline liver biopsy pre-2004 and a follow up liver fibrosis assessment more than 10 years later (biopsy or liver stiffness measurement (LSM) using transient elastography [FibroScan]) were identified. Subjects who had undergone a baseline liver biopsy but had no follow up fibrosis assessment were recalled for LSM. Fibrosis was categorised as mild-mo

SUBMITTER: Chen Yi Mei SLG 

PROVIDER: S-EPMC5655473 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature