Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration.

ABSTRACT: Chemokine-induced directional cell migration is a universal cellular mechanism and plays crucial roles in numerous biological processes, including embryonic development, immune system function, and tissue remodeling and regeneration. During the migration of a stationary cell, the cell polarizes, forms lamellipodia at the leading edge (LE), and triggers the concurrent retraction of the trailing edge (TE). During cell migration governed by inhibitory G protein (G_i)-coupled receptors (GPCRs), G protein βγ (Gβγ) subunits control the LE signaling. Interestingly, TE retraction has been linked to the activation of the small GTPase Ras homolog family member A (RhoA) by the Gα_12/13 pathway. However, it is not clear how the activation of G_i-coupled GPCRs at the LE or

SUBMITTER: Siripurapu P 

PROVIDER: S-EPMC5655523 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature