Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.

ABSTRACT: Renalase decreases circulating catecholamines concentration and is important in maintaining primary cellular metabolism. Renalase acts through the plasma membrane calcium ATPase 4b in the heart, which affects pressure overload but not exercise induced heart hypertrophy. The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left ventricular hypertrophy in a large cohort of patients with aortic stenosis. The study group consisted of 657 patients with aortic stenosis referred for aortic valve replacement. Preoperative echocardiographic assessment was performed to obtain cardiac phenotypes. Generalized-linear models were implemented to analyze data using crude or full model adjusted for selected clinical factors. In fe

SUBMITTER: Orlowska-Baranowska E 

PROVIDER: S-EPMC5655536 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature