SCRAMBLE'N'GAMBLE: a tool for fast and facile generation of random data for statistical evaluation of QSAR models.

ABSTRACT: A common practice in modern QSAR modelling is to derive models by variable selection methods working on large descriptor pools. As pointed out previously, this is intrinsically burdened with the risk of finding random correlations. Therefore it is desirable to perform tests showing the performance of models built on random data. In this contribution, we introduce a simple and freely available software tool SCRAMBLE'N'GAMBLE that is aimed at facilitating data preparation for y-randomization and pseudo-descriptors tests. Then, four close-to-real-world modelling situations are analysed. The tests indicate what the quality of obtained QSAR models is like in comparison to chance models derived from random data. The non-randomness is not the only requirement for a good QSAR model, however

SUBMITTER: Lipinski PFJ 

PROVIDER: S-EPMC5655615 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature