How radiation influences atherosclerotic plaque development: a biophysical approach in ApoE⁻/⁻ mice.

ABSTRACT: Atherosclerosis is the development of lipid-laden plaques in arteries and is nowadays considered as an inflammatory disease. It has been shown that high doses of ionizing radiation, as used in radiotherapy, can increase the risk of development or progression of atherosclerosis. To elucidate the effects of radiation on atherosclerosis, we propose a mathematical model to describe radiation-promoted plaque development. This model distinguishes itself from other models by combining plaque initiation and plaque growth, and by incorporating information from biological experiments. It is based on two consecutive processes: a probabilistic dose-dependent plaque initiation process, followed by deterministic plaque growth. As a proof of principle, experimental plaque size data from carotid arteries

SUBMITTER: Kloosterman A 

PROVIDER: S-EPMC5655690 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature