The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies.

ABSTRACT:

Objective

The level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures.

Methods

Dementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini-Mental State Examination (CAMCOG and MMSE) assessments. Hippocampal volume, and parahippocampal, entorhinal and temporal pole cortical thickness, was compared between groups. Regression models were used to investigate whether hippocampal volume and cortical thickness associated with global cognitio

SUBMITTER: Elder GJ 

PROVIDER: S-EPMC5655697 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature