FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder.

ABSTRACT:

Background

Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.

Methods

In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent ¹⁸ F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included ¹⁸ F-fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with

SUBMITTER: Meles SK 

PROVIDER: S-EPMC5655750 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature