Identification of copy number variation in French dairy and beef breeds using next-generation sequencing.

ABSTRACT:

Background

Copy number variations (CNV) are known to play a major role in genetic variability and disease pathogenesis in several species including cattle. In this study, we report the identification and characterization of CNV in eight French beef and dairy breeds using whole-genome sequence data from 200 animals. Bioinformatics analyses to search for CNV were carried out using four different but complementary tools and we validated a subset of the CNV by both in silico and experimental approaches.

Results

We report the identification and localization of 4178 putative deletion-only, duplication-only and CNV regions, which cover 6% of the bovine autosomal genome; they were validated by two in silico approaches and/or experimentally validated using array-based comparative gen

SUBMITTER: Letaief R 

PROVIDER: S-EPMC5655909 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature