Alternative splicing regulation in tumor necrosis factor-mediated inflammation.

ABSTRACT: It is generally accepted that alternative splicing has an effect on disease when it leads to conspicuous changes in relevant proteins, but that the combinatorial effect of several small modifications can have marked outcomes as well. Inflammation is a complex process involving numerous signaling pathways, among which the tumor necrosis factor (TNF) pathway is one of the most studied. Signaling pathways are commonly represented as intricate cascades of molecular interactions that eventually lead to the activation of one or several genes. Alternative splicing is a common means of controlling protein expression in time and space; therefore, it can modulate the outcome of signaling pathways through small changes in their elements. Notably, the overall process is tightly regulated, which is eas

SUBMITTER: Lopez-Urrutia E 

PROVIDER: S-EPMC5656035 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature