Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System.

ABSTRACT: Alternative polyadenylation (APA) is a widespread gene regulatory mechanism that generates mRNAs with different 3'-ends, allowing them to interact with different sets of RNA regulators such as microRNAs and RNA-binding proteins. Recent studies have shown that during development, neural tissues produce mRNAs with particularly long 3'UTRs, suggesting that such extensions might be important for neural development and function. Despite this, the mechanisms underlying neural APA are not well understood. Here, we investigate this problem within the Drosophila nervous system, focusing on the roles played by general cleavage and polyadenylation factors (CPA factors). In particular, we examine the model that modulations in CPA factor concentration may affect APA during development. For this, we fir

SUBMITTER: Vallejos Baier R 

PROVIDER: S-EPMC5656104 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature