Ontology highlight
ABSTRACT:
SUBMITTER: Salvador F
PROVIDER: S-EPMC5656180 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cancer research 20170718 21
The lysyl oxidase-like protein LOXL2 has been suggested to contribute to tumor progression and metastasis, but <i>in vivo</i> evidence has been lacking. Here we provide functional evidence that LOXL2 is a key driver of breast cancer metastasis in two conditional transgenic mouse models of PyMT-induced breast cancer. LOXL2 ablation in mammary tumor cells dramatically decreased lung metastasis, whereas LOXL2 overexpression promoted metastatic tumor growth. LOXL2 depletion or overexpression in tumo ...[more]