Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa.

ABSTRACT:

Background

Quorum sensing is a mechanism of intercellular communication that controls the production of virulence factors in Pseudomonas aeruginosa. Inhibition of quorum sensing can disarm the virulence factors without exerting stress on bacterial growth that leads to emergence of antibiotic resistance.

Objectives

Finding a new quorum sensing inhibitor and determining its inhibitory activities against virulence factors of Pseudomonas aeruginosa PAO1 strain.

Methods

Quorum sensing was evaluated by estimation of violacein production by Chromobacterium violaceum CV026. Molecular docking was used to investigate the possible binding of metformin to LasR and rhlR receptors. The inhibition of pyocyanin, hemolysin, protease, elastase in addition to swimmi

SUBMITTER: Abbas HA 

PROVIDER: S-EPMC5656202 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature