Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres.

ABSTRACT: Telomeres terminate nearly exclusively in single-stranded DNA (ssDNA) overhangs comprised of the G-rich 3' end. This overhang varies widely in length from species to species, ranging from just a few bases to several hundred nucleotides. These overhangs are not merely a remnant of DNA replication but rather are the result of complex further processing. Proper management of the telomeric overhang is required both to deter the action of the DNA damage machinery and to present the ends properly to the replicative enzyme telomerase. This Current Topic addresses the biochemical and structural features used by the proteins that manage these variable telomeric overhangs. The Pot1 protein tightly binds the single-stranded overhang, preventing DNA damage sensors from binding. Pot1 also orchestrates

SUBMITTER: Lloyd NR 

PROVIDER: S-EPMC5656232 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature