Identification of molecular alterations in leukocytes from gene expression profiles of peripheral whole blood of Alzheimer's disease.

ABSTRACT: Blood-based test has been considered as a promising way to diagnose and study Alzheimer's disease (AD). However, the changed proportions of the leukocytes under disease states could confound the aberrant expression signals observed in mixed-cell blood samples. We have previously proposed a method, Ref-REO, to detect the leukocyte specific expression alterations from mixed-cell blood samples. In this study, by applying Ref-REO, we detect 42 and 45 differentially expressed genes (DEGs) between AD and normal peripheral whole blood (PWB) samples in two datasets, respectively. These DEGs are mainly associated with AD-associated functions such as Wnt signaling pathways and mitochondrion dysfunctions. They are also reproducible in AD brain tissue, and tend to interact with the reported AD-associa

SUBMITTER: Li H 

PROVIDER: S-EPMC5656592 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature