Impaired BK_Ca channel function in native vascular smooth muscle from humans with type 2 diabetes.

ABSTRACT: Large-conductance Ca²⁺-activated potassium (BK_Ca) channels are key determinants of vascular smooth muscle excitability. Impaired BK_Ca channel function through remodeling of BK_Ca β1 expression and function contributes to vascular complications in animal models of diabetes. Yet, whether similar alterations occur in native vascular smooth muscle from humans with type 2 diabetes is unclear. In this study, we evaluated BK_Ca function in vascular smooth muscle from small resistance adipose arteries of non-diabetic and clinically diagnosed type 2 diabetic patients. We found that BK_Ca channel activity opposes pressure-induced constriction in human small resistance adipose arteries, and this is compromised in arteries from diabetic pa

SUBMITTER: Nieves-Cintron M 

PROVIDER: S-EPMC5656614 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature