Inhibition of lobuloalveolar development by FOXC1 overexpression in the mouse mammary gland.

ABSTRACT: The forkhead box transcription factor FOXC1 plays a critical role in embryogenesis and the development of many organs. Its mutations and high expression are associated with many human diseases including breast cancer. Although FOXC1 knockout mouse studies showed that it is not required for mammary gland development during puberty, it is not clear whether its overexpression alters normal mammary development in vivo. To address this question, we generated transgenic mice with mammary-specific FOXC1 overexpression. We report that transgenic FOXC1 overexpression suppresses lobuloalveologenesis and lactation in mice. This phenotype is associated with higher percentages of estrogen receptor-, progesterone receptor-, or ki67-positive mammary epithelial cells in the transgenic mice at the lactatio

SUBMITTER: Gao B 

PROVIDER: S-EPMC5656618 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature