Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform.

ABSTRACT: Wiring a series of simple logic gates to process complex data is significantly important and a large challenge for untraditional molecular computing systems. The programmable property of DNA endows its powerful application in molecular computing. In our investigation, it was found that DNA exhibits excellent peroxidase-like activity in a colorimetric system of TMB/H₂O₂/Hemin (TMB, 3,3', 5,5'-Tetramethylbenzidine) in the presence of K⁺ and Cu²⁺, which is significantly inhibited by the addition of an antioxidant. According to the modulated catalytic activity of this DNA-based catalyst, three cascade logic gates including AND-OR-INH (INHIBIT), AND-INH and OR-INH were successfully constructed. Interestingly, by only modulating the concentration of Cu

SUBMITTER: Gao J 

PROVIDER: S-EPMC5656625 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature