Altered Norbin Expression in Patients with Epilepsy and a Rat Model.

ABSTRACT: Norbin is widely distributed in neuronal tissues, is a regulator of Ca2⁺/calmodulin-dependent protein kinase II (CaMKII) phosphorylation. Norbin is also an important endogenous modulator of metabotropic glutamate receptor 5 (mGluR5) signaling, and nervous system-specific homozygous gene disruptions, result in epileptic seizures. In this study, we aimed to investigate norbin expression patterns in epilepsy and to elucidate the relationships between norbin and mGluR5 and p-CaMKII in epilepsy. Double-immunolabeling, immunohistochemistry and immunoblotting studies showed that norbin was downregulated in the temporal neocortex of patients with temporal lobe epilepsy (TLE) compared with control subjects. Moreover, in a rat model of lithium chloride-pilocarpine-induced epilepsy, norbin

SUBMITTER: Xu Y 

PROVIDER: S-EPMC5656659 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature