Remodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses.

ABSTRACT: The Streptococcus mutans Cid/Lrg system represents an ideal model to study how this organism withstands various stressors encountered in the oral cavity. Mutation of lrgAB renders S. mutans more sensitive to oxidative, heat, and vancomycin stresses. Here, we have performed a comprehensive proteomics experiment using label-free quantitative mass spectrometry to compare the proteome changes of wild type UA159 and lrgAB mutant strains in response to these same stresses. Importantly, many of identified proteins showed either a strikingly large fold-change, or were completely suppressed or newly induced in response to a particular stress condition. Notable stress proteome changes occurred in a variety of functional categories, including amino acid biosynthesis, energy metabolism, protein synthe

SUBMITTER: Ahn SJ 

PROVIDER: S-EPMC5656683 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature