Ontology highlight
ABSTRACT:
SUBMITTER: Cavadas M
PROVIDER: S-EPMC5656746 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell reports 20171001 3
Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage ("shedding") of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking of TACE within the secretory pathway requires its binding to iRhom2, which mediates the exit of TACE from the endoplasmic reticulum. An important, but mechanistically unclear, feature of TACE biology i ...[more]