High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression.

ABSTRACT: A high salt (HS) diet is detrimental to cognitive function, in addition to having a role in cardiovascular disorders. However, the method by which an HS diet impairs cognitive functions such as learning and memory remains open. In this study, we found that mice on a 7 week HS diet demonstrated disturbed short-term memory in an object-place recognition task, and both 4 week and 7 week HS treatments impaired long-term memory, as evidenced in a fear conditioning test. Mechanistically, the HS diet inhibited memory-related long-term potentiation (LTP) in the hippocampus, while also increasing the levels of reactive oxygen species (ROS) in hippocampal cells and downregulating the expression of synapsin I, synaptophysin, and brain-derived neurotrophic factor in specific encephalic region. This su

SUBMITTER: Ge Q 

PROVIDER: S-EPMC5656827 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature