SCARB1 Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease.

ABSTRACT:

Background/aim

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids.

Patients and methods

Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions.

Results

According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02).

Conclusion

The SCARB1AA genotype decreased c

SUBMITTER: Ayhan H 

PROVIDER: S-EPMC5656860 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature